Serum and Urinary Cytokine Homeostasis and Renal Tubular Function in Children with Type 1 Diabetes Mellitus
| Autor: | Anna Balcerska, Małgorzata Myśliwiec, Katarzyna Zorena, Beata S. Lipska, Piotr Wiśniewski, Andrzej Myśliwski, Jolanta Myśliwska |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Urinary system Urine urologic and male genital diseases Nephropathy Diabetic nephropathy Endocrinology Internal medicine Diabetes mellitus Acetylglucosaminidase medicine Albuminuria Homeostasis Humans Diabetic Nephropathies Child Interleukin 6 Type 1 diabetes biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry medicine.disease Isoenzymes Diabetes Mellitus Type 1 Pediatrics Perinatology and Child Health biology.protein Female Microalbuminuria business Biomarkers |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 2191-0251 0334-018X |
| Popis: | Aim To explore the relationships between tumor necrosis factor-alpha (TNFalpha), interleukin-6 (IL-6) and urinary N-acetyl-beta-D-glucosaminidase (NAG) and the function of renal proximal tubules in children with type 1 diabetes mellitus (DM1). Methods Fifty-six children with DM1 and 35 healthy controls were analyzed. We measured NAG (A and B isoforms) in urine as well as serum TNFalpha and urinary IL-6. Results The children with DM1 with microalbuminuria (group A) had significantly higher urinary IL-6 and serum TNFa than the children without microalbuminuria (group B). The diabetic patients with no sign of nephropathy showed significantly higher TNFalpha and NAG and its A and B isoforms in urine compared to the healthy group. Additionally, groups A and B both showed a positive significant correlation between serum TNFalpha and urinary isoform B. Conclusions From our pilot results it appears that TNFalpha might be a sensitive marker of damage to the renal proximal tubules occurring prior to microalbuminuria. Conversely, the increase in NAG and its isoform B activity in patients with no clinical sign of diabetic nephropathy may indicate the onset of microalbuminuria. |
| Databáze: | OpenAIRE |
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