Three Sickle Cell Anemia Patients Each with a Different α Chain Variant. Diagnostic Complications
| Autor: | L.-H. Gu, Titus H.J. Huisman, Virgil McKie, T. P. Molchanova, K. McKie, J. B. Wilson |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Heterozygote Hemoglobins Abnormal Hb SC-disease Clinical Biochemistry Anemia Sickle Cell Loss of heterozygosity Hb Chicago medicine Humans Child Chromatography High Pressure Liquid Genetics (clinical) business.industry Biochemistry (medical) Hematology Blood Protein Electrophoresis medicine.disease Molecular biology Sickle cell anemia Globins Hemoglobinopathies Hb Montgomery Child Preschool Immunology Female Hemoglobin Isoelectric Focusing business |
| Zdroj: | Hemoglobin. 17:295-301 |
| ISSN: | 1532-432X 0363-0269 |
| Popis: | We have studied three sickle cell anemia patients who also carried a heterozygosity for one of the following alpha chain abnormalities: Hb G-Philadelphia [alpha 68(E17)Asn--Lys], Hb Montgomery [alpha 48 (CE6)Leu--Arg], and Hb Chicago [alpha 136(H19)Leu--Met]. Electrophoretic analyses alone may result in incomplete and incorrect information. Confirmation of the diagnosis of Hb SS or Hb SC disease by one of the fast high performance liquid chromatographic procedures is recommended. |
| Databáze: | OpenAIRE |
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