Regeneration of rodent small intestine tissue following implantation of scaffolds seeded with a novel source of smooth muscle cells
| Autor: | Joydeep Basu, Namrata Sangha, John W. Ludlow, Kelly I. Guthrie, Toyin Knight, Deepak Jain, Elias A. Rivera, Richard G. Payne, Timothy A. Bertram, Kim L. Mihalko, Christopher W. Genheimer, Manuel J. Jayo |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Embryology Rodent Myocytes Smooth Muscle Cell Biomedical Engineering Adipose tissue Prosthesis Implantation Tissue engineering Smooth muscle biology.animal Intestine Small medicine Animals Regeneration Tissue Engineering Tissue Scaffolds biology Regeneration (biology) Anastomosis Surgical Biomaterial Anatomy Small intestine Rats Cell biology medicine.anatomical_structure Gene Expression Regulation Rats Inbred Lew Female |
| Zdroj: | Regenerative Medicine. 6:721-731 |
| ISSN: | 1746-076X 1746-0751 |
| DOI: | 10.2217/rme.11.78 |
| Popis: | Aims: To apply an organ regeneration platform technology of autologous smooth muscle cell/biomaterial combination products, previously demonstrated to be successful for urinary tissue regeneration, to the regeneration of the small intestine. Materials & methods: Patch and tubular constructs were implanted in rodent small intestines and histologically evaluated over a time course for evidence of regeneration of the laminarly organized neo-mucosa and muscle layers. Results: Laminarly organized neo-mucosa and muscle layer bundles are demonstrated as early as 8 weeks postimplantation. Conclusion: An organ regeneration technology platform of autologous smooth muscle cell/biomaterial combination products can be extended to the regeneration of the small intestine. |
| Databáze: | OpenAIRE |
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