Contrast leakage distant from the hematoma in patients with spontaneous ICH: A 7 T MRI study
| Autor: | Matthias J.P. van Osch, Floris H.B.M. Schreuder, Gabriel J.E. Rinkel, Koen M. van Nieuwenhuizen, Hugo J. Kuijf, Jeroen Hendrikse, Wilmar M.T. Jolink, Arjen Lindenholz, Ellis S. van Etten, Catharina J.M. Klijn, Marieke J.H. Wermer |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology small vessel disease Clinical Neurology Fluid-attenuated inversion recovery 030218 nuclear medicine & medical imaging Cohort Studies Blood–brain barrier 03 medical and health sciences 0302 clinical medicine Hematoma All institutes and research themes of the Radboud University Medical Center cerebral microbleeds medicine Journal Article magnetic resonance imaging Humans In patient cardiovascular diseases Blood-brain barrier Aged Cerebral Hemorrhage Intracerebral hemorrhage medicine.diagnostic_test business.industry Magnetic resonance imaging Original Articles Middle Aged medicine.disease Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] Magnetic Resonance Imaging intracerebral hemorrhage Pathophysiology nervous system diseases Cerebral Small Vessel Diseases Female Neurology (clinical) Radiology Cerebral amyloid angiopathy business Cardiology and Cardiovascular Medicine 030217 neurology & neurosurgery Extravasation of Diagnostic and Therapeutic Materials |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism Journal of Cerebral Blood Flow and Metabolism, 40, 5, pp. 1002-1011 Journal of Cerebral Blood Flow and Metabolism, 40, 1002-1011 Journal of Cerebral Blood Flow and Metabolism, 40(5), 1002-1011. SAGE PUBLICATIONS INC Journal of Cerebral Blood Flow and Metabolism, 40(5), 1002. Nature Publishing Group |
| ISSN: | 1559-7016 0271-678X |
| Popis: | Disruption of the blood–brain barrier (BBB) might play a role in the pathophysiology of cerebral small vessel disease-related ICH. The aim of this study was to assess presence and extent of contrast agent leakage distant from the hematoma as a marker of BBB disruption in patients with spontaneous ICH. We prospectively performed 7 tesla MRI in adult patients with spontaneous ICH and assessed contrast leakage distant from the hematoma on 3D FLAIR images. Thirty-one patients were included (mean age 60 years, 29% women). Median time between ICH and MRI was 20 days (IQR 9–67 days). Seventeen patients (54%; seven lobar, nine deep, one infratentorial ICH) had contrast leakage, located cortical in 16 and cortical and deep in one patient. Patients with contrast leakage more often had lobar cerebral microbleeds (CMBs; 77%) than those without (36%; RR 2.5, 95% CI 1.1–5.7) and a higher number of lobar CMBs (patients with contrast leakage: median 2, IQR 1–8 versus those without: median 0, IQR 0–2; p = 0.02). This study shows that contrast leakage distant from the hematoma is common in days to weeks after spontaneous ICH. It is located predominantly cortical and related to lobar CMBs and therefore possibly to cerebral amyloid angiopathy. |
| Databáze: | OpenAIRE |
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