Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones

Autor:	Sonia Varón, Ricardo Pérez-Tomás, Anna Aviñó, Fernando Albericio, Ramon Eritja, Isabel Navarro, Miriam Royo, Natalia G. Beteta, Juan Aymami, Josep Farrera-Sinfreu, Wilmar Castillo-Ávila
Rok vydání:	2008
Předmět:	Stereochemistry Molecular Sequence Data Clinical Biochemistry Carboxylic Acids Pharmaceutical Science Antineoplastic Agents Peptide Biochemistry Chemical synthesis Oligomer Inhibitory Concentration 50 Mice Structure-Activity Relationship chemistry.chemical_compound Solid-phase synthesis Cell Line Tumor Amide Drug Discovery Animals Humans Amino Acid Sequence Amino Acids Molecular Biology chemistry.chemical_classification Peptide nucleic acid Organic Chemistry Chromophore Amides Fluorescence chemistry Drug Design Molecular Medicine Peptides
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:2440-2444
ISSN:	0960-894X
Popis:	The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c32c96cadbf3db0c00d68bc3e017a15 https://doi.org/10.1016/j.bmcl.2008.02.045 Zobrazit plný text záznamu Full Text from ScienceDirect