Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis
| Autor: | Fernando Fernandes, Rudá Alessi, Silvia Vincentiis, Bernardo dos Santos, Juliana Alcantara, Helio van der Linden, Wagner F. Gattaz, Renata Demarque, Geraldo F. Busatto, Mauricio H. Serpa, Daniel S. Kerr, Ricardo Alberto Moreno, Kette D. Valente, Patricia Rzezak, Tiffany M. Chaim-Avancini, Francisco Arruda |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Serotonergic Hippocampus behavioral disciplines and activities Temporal lobe 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Internal medicine Humans Medicine 030212 general & internal medicine Depression (differential diagnoses) Serotonin transporter Serotonin Plasma Membrane Transport Proteins Depressive Disorder Major Hippocampal sclerosis Polymorphism Genetic Sclerosis biology Depression business.industry medicine.disease nervous system diseases Epilepsy Temporal Lobe nervous system Neurology Mood disorders biology.protein Major depressive disorder Neurology (clinical) business Brazil psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Epilepsy & Behavior. 117:107854 |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2021.107854 |
| Popis: | Background Mood disorders are the most frequent psychiatric disorders in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS). The pathophysiological mechanisms in common between TLE and mood disorders include abnormalities in the serotonergic pathway. We aimed to evaluate the association between serotonin transporter genetic polymorphisms – 5-HTTLPR and 5-HTTVNTR – and the presence of mood disorders in patients with TLE-HS. Methods We evaluated 119 patients with TLE-HS, with and without psychiatric disorder; 146 patients diagnosed with major depressive disorder (MDD), and 113 healthy volunteers. Individuals were genotyped for the 5-HTTLPR and 5-HTTVNTR polymorphisms. Results No difference was observed between the TLE-HS groups, healthy controls, and MDD without epilepsy. There was a correlation between the 12-allele of the 5-HTTVNTR and the family history of patients with epilepsy with TLE-HS (p = 0.013). Conclusions In this study conducted in two Brazilian centers, the serotonin transporter polymorphisms evaluated cannot be associated with depressive disorder in patients with TLE-HS. Still, they do have some influence over some clinical characteristics of epilepsy in TLE-HS. These data may not be reproduced in other populations with distinct ethnic characteristics. |
| Databáze: | OpenAIRE |
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