Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression
| Autor: | Wen-Qian Tang, Jiang-Hong Gu, Chun-Hui Ji, Jie Zhao, Yin Zhang, Yue Liu, Bo Jiang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Niacinamide Tropomyosin receptor kinase B Pharmacology Hippocampal formation Hippocampus 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Medicine Hippocampus (mythology) Animals Brain-derived neurotrophic factor Nicotinamide Dose-Response Relationship Drug business.industry Depression General Neuroscience Brain-Derived Neurotrophic Factor Tail suspension test Antidepressive Agents Mice Inbred C57BL Disease Models Animal 030104 developmental biology chemistry Hindlimb Suspension Chronic Disease Antidepressant business 030217 neurology & neurosurgery Stress Psychological Behavioural despair test |
| Zdroj: | Neuroscience letters. 742 |
| ISSN: | 1872-7972 |
| Popis: | Depression is one of the most common psychiatric disorders, and there is strong demand for developing novel antidepressants with better efficacy and less adverse effects. 1-Methylnicotinamide (MNA) is a main metabolite of nicotinamide and has been demonstrated to possess biological effects in the brain. This study aimed to evaluate the antidepressant-like effects of MNA in mice, and the possible antidepressant mechanism was also determined. The forced swim test (FST), tail suspension test (TST), chronic unpredictable mild stress (CUMS) model of depression, western blotting method and K252a (a pharmacological inhibitor of the BDNF receptor) were used together in the present study. It was found that a single injection of MNA (100 and 200 mg/kg) displayed notable antidepressant-like potential in the FST and TST without affecting the locomotor activity of mice. Repeated administration of MNA (100 and 200 mg/kg) for 2 weeks fully reversed not only the CUMS-induced depressive-like symptoms in mice but also the CUMS-induced decrease in the hippocampal BDNF signaling pathway. Furthermore, the usage of K252a fully blocked the antidepressant-like effects of MNA in the FST, TST and CUMS model of depression. Collectively, MNA possess an antidepressant-like effect in mice which is mediated, at least in part, through promoting the hippocampal BDNF signaling pathway. |
| Databáze: | OpenAIRE |
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