Macrophages, Meta-Inflammation, and Immuno-Metabolism
| Autor: | Aviv Lutaty, Haim Shapiro, Amiram Ariel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adipose tissue macrophages
Adipose tissue lcsh:Medicine Inflammation Review Article inflamation Biology Mitochondrion lcsh:Technology General Biochemistry Genetics and Molecular Biology Immune system insulin resistance Adipocytes medicine Humans Insulin Macrophage Obesity lcsh:Science General Environmental Science lcsh:T Macrophages lcsh:R General Medicine Macrophage Activation Cell Hypoxia Mitochondria Cell biology PPAR gamma Phenotype Adipose Tissue Mitochondrial biogenesis Anaerobic glycolysis Immunology lcsh:Q medicine.symptom Energy Metabolism metabolism Glycolysis Signal Transduction |
| Zdroj: | The Scientific World Journal, Vol 11, Pp 2509-2529 (2011) The Scientific World Journal |
| Popis: | Current research depicts specific modes of immunity and energy metabolism as being interrelated at the molecular, cellular, organ and organism level. Hence, whereas M2 (alternatively-activated) macrophages dominate insulin-sensitive adipose tissue in the lean, M1-skewed (classically-activated) macrophages accumulate in parallel to adiposity in the obese, and promote inflammation and insulin resistance, that is, meta-inflammation. The latest frontier of immuno-metabolism explores the coregulation of energy metabolism and immune function within hematopoietic cells. M1-skewed macrophages are sustained in edematous, hypoxic tissues by anaerobic glycolysis, whereas mitochondrial biogenesis and respiration dominates in M2 cells. We review the underlying mechanisms and the consequences of the transition from M2 to M1 predominance in adipose tissue, as well as the extracellular signals and transcription factors that control macrophage phenotypes and impose distinct metabolic modes. |
| Databáze: | OpenAIRE |
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