Kaposi’s sarcoma-associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case–control study in Xinjiang, China
| Autor: | Jun Zheng, Juan Zhao, Yan Zeng, Charles E. Wood, Qiwen Fang, Cui Meng, Ya-Ge Fan, Yin Chen, Tiejun Zhang, Zhan-Jun Shu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine Microbiology (medical) China medicine.medical_specialty 030106 microbiology Antibodies Viral lcsh:Infectious and parasitic diseases Body Mass Index 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Internal medicine Diabetes mellitus Humans Medicine Seroprevalence lcsh:RC109-216 030212 general & internal medicine Antigens Viral Sarcoma Kaposi business.industry Case-control study Antibody titer Type 2 Diabetes Mellitus General Medicine Odds ratio Middle Aged Viral Load medicine.disease Infectious Diseases Diabetes Mellitus Type 2 Case-Control Studies Herpesvirus 8 Human Female business Viral load Body mass index |
| Zdroj: | International Journal of Infectious Diseases, Vol 80, Iss, Pp 73-79 (2019) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2019.01.003 |
| Popis: | Objective: To assess the potential relationship between Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China. Methods: A case–control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were investigated. Logistic regression analysis and multiple linear regression analysis were applied to explore determinants of the main outcome measures. Results: A total of 324 patients with DM-2 and 376 normal controls were included. The seroprevalence of KSHV was 49.1% (95% confidence interval (CI) 43.6–54.5%) for diabetic patients and 23.7% (95% CI 19.4–28.0%) for the control group. After adjusting for variables of ethnicity, sex, body mass index, occupation, educational level, marital status, age, and smoking and alcohol consumption habits, the association between DM-2 and KSHV infection still existed (odds ratio (OR) 2.94, 95% CI 2.05–4.22), and the risk of KSHV infection increased with glucose concentration (OR 1.35, 95% CI 1.21–1.51). KSHV was more likely to express both the latent and lytic antigens in diabetic patients (latent: OR 3.27, 95% CI 2.25–4.75; lytic: OR 3.99, 95% CI 2.68–5.93). Antibody titers and viral load increased in patients with higher blood glucose levels (p |
| Databáze: | OpenAIRE |
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