When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms
| Autor: | Pascal Vaudin, Corinne Augé, Nathalie Just, Sakina Mhaouty-Kodja, Stéphane Mortaud, Delphine Pillon |
|---|---|
| Přispěvatelé: | Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
0303 health sciences
Wastewater Biochemistry 3. Good health 03 medical and health sciences 0302 clinical medicine Pharmaceutical Preparations Environmental Pollutants [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Water Pollutants Chemical 030217 neurology & neurosurgery ComputingMilieux_MISCELLANEOUS Environmental Monitoring 030304 developmental biology General Environmental Science |
| Zdroj: | Environmental Research Environmental Research, Elsevier, 2022, 205, pp.112495. ⟨10.1016/j.envres.2021.112495⟩ |
| ISSN: | 0013-9351 1096-0953 |
| DOI: | 10.1016/j.envres.2021.112495⟩ |
| Popis: | Pharmaceutical drugs have become consumer products, with a daily use for some of them. The volume of production and consumption of drugs is such that they have become environmental pollutants. Their transfer to wastewater through urine, feces or rinsing in case of skin use, associated with partial elimination by wastewater treatment plants generalize pollution in the hydrosphere, including drinking water, sediments, soils, the food chain and plants. Here, we review the potential effects of environmental exposure to three classes of pharmaceutical drugs, i.e. antibiotics, antidepressants and non-steroidal anti-inflammatory drugs, on neurodevelopment. Experimental studies analyzing their underlying modes of action including those related to endocrine disruption, and molecular mechanisms including epigenetic modifications are presented. In addition, the contribution of brain imaging to the assessment of adverse effects of these three classes of pharmaceuticals is approached. |
| Databáze: | OpenAIRE |
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