Use of percutaneous image‐guided coaxial core‐needle biopsy for diagnosis of intraabdominal lymphoma

Autor:	Yuki Hiroshima, Keijiro Sato, Hikaru Kobayashi, Naoaki Ichikawa, Yoichi Okazaki, Masahiko Sumi, Ikuo Shimizu, Wataru Takeda, Takehiko Kirihara, Mayumi Ueno, Yuko Fujikawa, Toshimitsu Ueki
Rok vydání:	2014
Předmět:	Adult Image-Guided Biopsy Male Cancer Research medicine.medical_specialty Percutaneous Lymphoma Immunophenotyping Young Adult Diagnosis Biopsy Humans Medicine Radiology Nuclear Medicine and imaging Sampling (medicine) Abdominal Neoplasms Original Research Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Clinical Cancer Research needle biopsy Retrospective cohort study Middle Aged medicine.disease immunophenotype Chromosome Banding Surgery Oncology sensitivity and specificity malignant lymphoma Female Radiology business Abdominal surgery
Zdroj:	Cancer Medicine
ISSN:	2045-7634
DOI:	10.1002/cam4.224
Popis:	Although pathological diagnosis is essential for managing malignant lymphoma, intraabdominal lesions are generally difficult to approach due to the invasiveness of abdominal surgery. Here, we report the use of percutaneous image-guided coaxial core-needle biopsy (CNB) to obtain intraabdominal specimens for diagnosing intraabdominal lymphomas, which typically requires histopathological and immunohistochemical evaluation. We retrospectively reviewed consecutive cases involving computed tomography (CT)- or ultrasonography (US)-guided CNB to obtain pathological specimens for intraabdominal lesions from 1999 to 2011. Liver, spleen, kidney, and inguinal node biopsies were excluded. We compared CNBs with laparotomic biopsies. A total of 66 CNBs were performed for 59 patients (32 males, 27 females; median age, 63.5), including second or third repeat procedures. Overall diagnostic rate was 88.5%. None of the patients required additional surgical biopsies. Notably, the median interval between recognition of an intraabdominal mass and biopsy was only 1 day. Forty-five procedures were performed for hematological malignancies. Adequate specimens were obtained for histopathological diagnosis in 86% of cases. Flow cytometry detected lymphoma cells in 79.5% of cases. Twelve patients (nine males, three females; median age, 60) were eligible for surgical biopsy. While every postoperative course was satisfactory, median duration from lesion recognition to therapy initiation for lymphoma cases was significantly shorter for CNB than for surgical biopsy (14 vs. 35 days). While one-fourth of the patients were not eligible for the procedures, CNB is safe and highly effective for diagnosis of intraabdominal lymphomas. This method significantly improves sampling and potentially helps attain immunohistological distinction, allowing for more timely therapy initiation.
Databáze:	OpenAIRE
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