Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women

Autor: Peter Grabowski, Jai Prakash, Gaurav Garg, Timothy M. Skerry, Jitender Kumar, Gareth O. Richards, Fiona E. McGuigan, Kristina Åkesson, Maria Herlin
Rok vydání: 2018
Předmět:
0301 basic medicine
medicine.medical_specialty
Bone density
lcsh:QH426-470
Population
CGRP
Calcitonin Gene-Related Peptide
SNP
Single Nucleotide Polymorphism
SNP
Single-nucleotide polymorphism
Biology
Article
KO
Knock-out
03 medical and health sciences
0302 clinical medicine
BMD
Internal medicine
Genotype
BMD
Bone Mineral Density
Genetics
medicine
RAMP3
Receptor Activity Modifying Protein 3
FM
Fat Mass
education
TB
Total Body
LM
Lean Mass
Bone mineral
education.field_of_study
CLR
Calcitonin Like-Receptor
RAMP3
General Medicine
OPRA
Osteoporosis Prospective Risk Assessment
LS
Lumbar Spine
FN
Femoral Neck
AM2R
Adrenomedullin-2 Receptor
lcsh:Genetics
030104 developmental biology
Endocrinology
Fracture
Fat
030220 oncology & carcinogenesis
Cohort
AM1R
Adrenomedullin-1 Receptor
Lean body mass
Gene polymorphism
AMY3
Amylin Receptor Complex
GPCR
G-Protein Coupled Receptor
Zdroj: Gene: X, Vol 2, Iss, Pp-(2019)
Gene: X
ISSN: 1879-0038
Popis: Background and aim The Receptor Activity Modifying Proteins (RAMPs) are a group of accessory proteins, of which there are three in humans, that interact with a number of G-protein coupled receptors (GPCR) and play various roles in regulation of endocrine signaling. Studies in RAMP3 knockout (KO) mice reveal an age related phenotype with altered metabolic regulation and high bone mass. To translate these findings into a clinically relevant perspective, we investigated the association between RAMP3 gene variants, body composition and bone phenotypes in two population-based cohorts of Swedish women. Methods Five single nucleotide polymorphisms (SNP) in the vicinity of the RAMP3 gene were genotyped in the PEAK-25 cohort (n = 1061; 25 years) and OPRA (n = 1044; 75 years). Bone mineral density (BMD), fat mass and lean mass (total body; regional) were measured by DXA at baseline, 5 and 10 year follow-up. Results BMD did not differ with RAMP3 genotype in either cohort, although fracture risk was increased in the elderly women (OR 2.695 [95% CI 1.514–4.801]). Fat mass tended to be higher with RAMP3 SNPs; although only in elderly women. In the young women, changes in BMI and fat mass between ages 25–35 differed by genotype (p = 0.001; p
Databáze: OpenAIRE
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