Relative comparison of catalytic characteristics of human foamy virus and HIV-1 integrases
| Autor: | O. V. Kondrashina, Ekaterina Knyazhanskaya, Maksim Smolov, Marina Gottikh |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
biology viruses Vectors in gene therapy Integrases Human foamy virus biology.organism_classification HIV – (HUMAN IMMUNODEFICIENCY VIRUS) HFV – (HUMAN FOAMY VIRUS) Biochemistry Virology Genome Virus Integrase Catalysis Enzyme chemistry biology.protein Molecular Medicine Molecular Biology Biotechnology |
| Zdroj: | Acta Naturae (англоязычная версия). |
| ISSN: | 2075-8251 |
| Popis: | Due to their ability to integrate into the host cell's genome, retroviruses represent an optimal basis for the creation of gene therapy vectors. The integration reaction is carried out by a viral enzyme integrase: thus, a detailed research of this enzyme is required. In this work, the catalytic properties of human foamy virus integrase were studied. This virus belongs to the Retroviridae family. The dissociation constant was determined, together with the kinetics of integrase catalytic activity. The data obtained were compared to those for the human immunodeficiency virus integrase and a considerable similarity in the activity of the two enzymes was observed. |
| Databáze: | OpenAIRE |
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