Vitamin D receptor FokI, TaqI, and ApaI polymorphisms and susceptibility to systemic lupus erythematosus: an updated meta-analysis
| Autor: | Young Ho Lee, Sang Cheol Bae |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine medicine.medical_specialty TaqI Calcitriol receptor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Internal medicine medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease Allele skin and connective tissue diseases Foki polymorphism 030203 arthritis & rheumatology biology business.industry Deoxyribonucleases Type I Site-Specific General Medicine FokI 030104 developmental biology chemistry Meta-analysis Case-Control Studies Immunology biology.protein Arab population Receptors Calcitriol business Polymorphism Restriction Fragment Length |
| Zdroj: | Clinical rheumatology. 37(6) |
| ISSN: | 1434-9949 |
| Popis: | This study aimed to explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). Meta-analyses were conducted to determine the associations between the VDR FokI, TaqI, and ApaI polymorphisms and SLE in all subjects and each ethnic group. A total of 12 studies were considered in the meta-analysis, which involved 1974 patients and 2506 controls. Meta-analysis of the VDR FokI polymorphism showed no association between SLE and the FokI F allele in all study subjects (OR = 1.047, 95% CI = 0.781–1.403, p = 0.758). However, the meta-analysis showed a significant association between SLE and the VDR FokI F allele in the Arab population (OR = 1.721, 95% CI = 1.417–2.088, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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