A112 EARLY USE OF THERAPEUTIC DRUG MONITORING TO INDIVIDUALIZE INFLIXIMAB THERAPY IN PAEDIATRIC IBD: A MULTICENTRE PROSPECTIVE COHORT STUDY

Autor: Crowley, E, Carman, N J, Arpino, V, Frost, K, Ricciuto, A, Sherlock, M, Critch, J, Mack, D R, Benchimol, E I, Jacobson, K, Lawrence, S, deBruyn, J, EL-MATARY, W, Otley, A, Huynh, H Q, Church, P C, Walters, T D, Griffiths, A
Rok vydání: 2018
Předmět:
Zdroj: Journal of the Canadian Association of Gastroenterology. 1:197-198
ISSN: 2515-2092
2515-2084
Popis: BACKGROUND: Utilization of therapeutic drug monitoring (TDM) to individualize biologic therapy is a logical strategy, given the variable drug clearance and multiple factors influencing pharmacokinetics. Indeed, previously documented wide variability of infliximab levels have been observed early post induction in pediatric patients. However, a randomized controlled trial in adults did not demonstrate improved outcomes with TDM implemented following induction phase of infliximab treatment. AIMS: The aim of the study was to determine infliximab trough levels during induction therapy in children with IBD, with the goal to pre-emptively personalize maintenance dosing. METHODS: Beginning in May 2016, children with IBD at participating sites in the Canadian Children IBD Network, when prescribed 3-dose infliximab induction therapy via either standard or intensified regimen, had pre-infusion trough levels measured by ELISA at the time of 3(rd) dose. An algorithm incorporating this trough level and the interval between doses 2 and 3 was used to determine timing and dose of first maintenance infusion, aiming to provide a trough level of 5–10 ug/mL when tested before dose 4. Induction regimens were at the discretion of the treating physician, but often intensified among patients with severe UC. Influence of patient demographics and baseline clinical disease activity (physician global assessment and wPCDAI or PUCAI) on early trough levels were assessed. RESULTS: From May to October 2016 at 6 participating sites, 77 children (mean age 12.4 years, 57% male, 53% CD, 47% UC/IBD-U) received 3-dose infliximab induction. CD patients were infused in standard fashion at weeks 0, 2, 6 with a mean dose of 5.5mg/kg/dose and concomitant immunomodulation (93% methotrexate; 7 % azathioprine); median pre-dose 3 IFX level was 11.9ug/ml (IQR: 8.5–27.2). UC/IBD-U patients (18% steroid-dependent, 82% steroid-refractory) received more drug (mean 6.8mg/kg/dose across 3 doses) and via an intensified regimen in 34%. Pre-dose 3 IFX levels (median 13.5ug/ml;IQR: 4.9–24.3) were comparable to CD despite higher dosing. 25% of UC/IBD-U patients vs. 11% of CD patients had infliximab trough level
Databáze: OpenAIRE
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