Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies
| Autor: | Pablo N Perez-Guzman, Kate Davis, Amy C. Justice, Edward W. Gregg, Annika Hoyer, Ralph Brinks, Keri N. Althoff, Simon Gregson, Mikaela Smit, Peter Reiss |
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| Přispěvatelé: | Global Health, Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, Wellcome Trust, Medical Research Council (MRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cross-sectional study
Human immunodeficiency virus (HIV) BLOOD-PRESSURE HIV Infections 030204 cardiovascular system & hematology medicine.disease_cause Global Health 0302 clinical medicine ANTIRETROVIRAL THERAPY Risk Factors Global health 030212 general & internal medicine SUB-SAHARAN AFRICA 11 Medical and Health Sciences METABOLIC SYNDROME CARDIOVASCULAR RISK General Medicine Middle Aged PREVALENCE 3. Good health Meta-analysis Hypertension Blood pressure Medicine Life Sciences & Biomedicine Research Article Adult ACUTE MYOCARDIAL-INFARCTION MEDLINE 03 medical and health sciences Medicine General & Internal PEOPLE General & Internal Medicine medicine Humans Aged Science & Technology business.industry Correction HIV IMMUNODEFICIENCY-VIRUS-INFECTION Cross-Sectional Studies Relative risk RISK-FACTORS Systematic review Observational study business Demography |
| Zdroj: | BMC Medicine, Vol 19, Iss 1, Pp 1-16 (2021) BMC Medicine BMC medicine, 19(1):105. BioMed Central |
| ISSN: | 1741-7015 |
| Popis: | Background Improved access to effective antiretroviral therapy has meant that people living with HIV (PLHIV) are surviving to older ages. However, PLHIV may be ageing differently to HIV-negative individuals, with dissimilar burdens of non-communicable diseases, such as hypertension. While some observational studies have reported a higher risk of prevalent hypertension among PLHIV compared to HIV-negative individuals, others have found a reduced burden. To clarify the relationship between HIV and hypertension, we identified observational studies and pooled their results to assess whether there is a difference in hypertension risk by HIV status. Methods We performed a global systematic review and meta-analysis of published cross-sectional studies that examined hypertension risk by HIV status among adults aged > 15 (PROSPERO: CRD42019151359). We searched MEDLINE, EMBASE, Global Health and Cochrane CENTRAL to August 23, 2020, and checked reference lists of included articles. Our main outcome was the risk ratio for prevalent hypertension in PLHIV compared to HIV-negative individuals. Summary estimates were pooled with a random effects model and meta-regression explored whether any difference was associated with study-level factors. Results Of 21,527 identified studies, 59 were eligible (11,101,581 participants). Crude global hypertension risk was lower among PLHIV than HIV-negative individuals (risk ratio 0.90, 95% CI 0.85–0.96), although heterogeneity between studies was high (I2 = 97%, p Conclusions Our findings suggest that the relationship between HIV status and prevalent hypertension differs by region. The results highlight the need to tailor hypertension prevention and care to local contexts and underscore the importance of rapidly optimising integration of services for HIV and hypertension in the worst affected regions. The role of different risk factors for hypertension in driving context-specific trends remains unclear, so development of further cohorts of PLHIV and HIV-negative controls focused on this would also be valuable. |
| Databáze: | OpenAIRE |
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