Cerebrospinal Fluid Concentrations of Biogenic Amines and Corticotropin-releasing Factor in Adolescent Non-human Primates as a Function of the Timing of Adverse Early Rearing
| Autor: | Eric L. Smith, Bruce Scharf, Jack M. Gorman, Charles B. Nemeroff, Sanjay J. Mathew, J. John Mann, Leonard A. Rosenblum, Michael J. Owens, Jeremy D. Coplan |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Corticotropin-Releasing Hormone Physiology Stimulus (physiology) Behavioral Neuroscience chemistry.chemical_compound Cerebrospinal fluid Neurochemical biology.animal Internal medicine medicine Animals Primate Sexual Maturation Maternal Behavior Bonnet macaque Behavior Animal biology Endocrine and Autonomic Systems Homovanillic acid Homovanillic Acid Fear Hydroxyindoleacetic Acid biology.organism_classification Psychiatry and Mental health Macaca radiata Neuropsychology and Physiological Psychology Endocrinology Monoamine neurotransmitter Social Dominance chemistry Female Psychology Stress Psychological hormones hormone substitutes and hormone antagonists |
| Zdroj: | Stress. 5:185-193 |
| ISSN: | 1607-8888 1025-3890 |
| Popis: | Adolescent bonnet macaques nursed as infants by mothers facing unpredictable requirements for food procurement (variable foraging demand, VFD) display persistent neurobiological disturbances. This study examined the long-term neurochemical and behavioral effects of adverse rearing initiated later in infancy than in previous cohorts of subjects to test the hypothesis that the timing of an early adverse experience would influence patterns of biobehavioral outcome. Cisternal cerebrospinal fluid (CSF) monoamine and corticotropin-releasing factor (CRF) concentrations were obtained from 20 bonnet macaques (11 VFD-reared and 9 normally reared controls) approximately 2 years after the end of differential rearing. VFD-reared primates displayed on multiple samplings significantly lower CSF CRF concentrations and higher CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration compared to controls. In the VFD-reared, significant inverse correlations between CRF and all three monoamines were found (5-HIAA, 3-methoxy-4-hydroxyphenethyleneglycol and homovanillic acid), most prominently for 5-HIAA. In controls, but not VFD-reared subjects, CSF CRF was positively correlated with changes in "gregariousness" upon presentation of a fear stimulus. VFD-reared subjects displayed greater baseline hierarchical engagement than controls. In contrast to prior findings, in which rearing under VFD conditions at an earlier age led to increased CSF CRF compared with controls, CSF CRF was lower after later exposure to VFD rearing than in controls. Thus, the timing of exposure to VFD conditions early in life evidently determines whether CSF CRF was found to be elevated or decreased, within the context of increased serotonin metabolism, during the course of primate maturation. |
| Databáze: | OpenAIRE |
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