Not all newborns born to mothers with clinical chorioamnionitis need to be treated
| Autor: | Neli Ujirauli, Orna Flidel-Rimon, Alex Guri, Ada Juster Reicher, Shachar Oren, Calanit Hershkovich-Shporen, Noa Gadassi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty Mothers Streptococcal disease Chorioamnionitis Group B 03 medical and health sciences 0302 clinical medicine Early onset sepsis Pregnancy Sepsis 030225 pediatrics medicine Humans 030212 general & internal medicine Retrospective Studies Early onset Clinical chorioamnionitis business.industry Infant Newborn Infant Obstetrics and Gynecology Antibiotic Prophylaxis medicine.disease Disease control Anti-Bacterial Agents Pediatrics Perinatology and Child Health Female business |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 34:1949-1954 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2019.1651281 |
| Popis: | The 2010 recommendations of the Centers for Disease Control and Prevention (CDC) for prevention of perinatal group B Streptococcal Disease (GBS) is that symptomatic newborns suspect for early onset sepsis (EOS), or newborns born to mothers with clinical chorioamnionitis should receive antibiotic treatment. Our protocol was changed accordingly during 2015. We prospectively assessed the safety of the protocol and evaluated the need to treat all newborns born to mothers with clinical chorioamnionitis and retrospectively evaluated the performance of the EOS risk calculator.The study period was from May 2015 to April 2016 at the Kaplan Medical Center (KMC). Inclusion criteria were: gestational age of 35 weeks and above, newborns that were treated with antibiotic, newborn born to mothers with risk factors for EOS or with maternal clinical chorioamnionitis, or to mothers that were given intra-partum antibiotic prophylaxis (IAP).In the study period, 7058 newborns were born, 1341 (19%) neonates were included according to the inclusion criteria. Six newborns had EOS (0.85 per 1000 live born). 123/1341 (9%) of the neonates were symptomatic of whom six (4.9%) had proven EOS with RR 10.9 (CI 3.5-33.39,We suggest that asymptomatic newborns born to mothers with clinical chorioamnionitis should not receive antibiotic treatment automatically. |
| Databáze: | OpenAIRE |
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