Management of acute skin toxicity with Hypericum perforatum and neem oil during platinum-based concurrent chemo-radiation in head and neck cancer patients
| Autor: | Pierfrancesco Franco, Oliviero Ostellino, Stefania Martini, Massimo Fasolis, C. Cavallin, Umberto Ricardi, Marina Schena, Francesca Arcadipane, Paolo Garzino Demo, Mario Airoldi, Monica Rampino, Giancarlo Pecorari |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_treatment Concomitant chemo-radiotherapy Head and neck cancer Hypericum perforatum Neem oil Skin toxicity Hematology Oncology Gastroenterology 0302 clinical medicine biology General Medicine Chemoradiotherapy Middle Aged Head and Neck Neoplasms 030220 oncology & carcinogenesis Toxicity Female Drug Eruptions Radiodermatitis Hypericum medicine.drug Adult medicine.medical_specialty Glycerides 03 medical and health sciences Internal medicine medicine Humans Aged Cisplatin Chemotherapy business.industry Terpenes biology.organism_classification medicine.disease Surgery 030104 developmental biology Concomitant business Phytotherapy |
| Popis: | Acute skin toxicity is a frequent finding during combined radiotherapy and chemotherapy in head and neck cancer patients. Its timely and appropriate management is crucial for both oncological results and patient's global quality of life. We herein report clinical data on the use of Hypericum perforatum and neem oil in the treatment of acute skin toxicity during concurrent chemo-radiation for head and neck cancer. A consecutive series of 50 head and neck cancer patients undergoing concomitant radio-chemotherapy with weekly cisplatin was analyzed. Treatment with Hypericum perforatum and neem oil was started in case of G2 acute skin toxicity according to the RTOG/EORTC scoring scale and continued during the whole treatment course and thereafter until complete recovery. The maximum detected acute skin toxicity included Grade 2 events in 62% of cases and G3 in 32% during treatment and G2 and G3 scores in 52 and 8%, respectively, at the end of chemo-radiation. Grade 2 toxicity was mainly observed during weeks 4-5, while G3 during weeks 5-6. Median times spent with G2 or G3 toxicity were 23.5 and 14 days. Patients with G3 toxicity were reconverted to a G2 profile in 80% of cases, while those with a G2 score had a decrease to G1 in 58% of cases. Time between maximum acute skin toxicity and complete skin recovery was 30 days. Mean worst pain score evaluated with the Numerical Rating Scale-11 was 6.9 during treatment and 4.5 at the end of chemo-radiotherapy. Hypericum perforatum and neem oil proved to be a safe and effective option in the management of acute skin toxicity in head and neck cancer patients submitted to chemo-radiation with weekly cisplatin. Further studies with a control group and patient-reported outcomes are needed to confirm this hypothesis. |
| Databáze: | OpenAIRE |
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