NIR‐II Fluorescent Brightness Promoted by 'Ring Fusion' for the Detection of Intestinal Inflammation
| Autor: | Menglei Zha, Jen-Shyang Ni, Yaxi Li, Guang Yang, Shuxian Wang, Kai Li |
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| Rok vydání: | 2021 |
| Předmět: |
Inflammation
Brightness Fusion Fluorescence-lifetime imaging microscopy Fluorophore Chemistry business.industry Optical Imaging Organic Chemistry Nanoparticle General Chemistry Fluorescence Acceptor Catalysis Planarity testing Mice chemistry.chemical_compound Animals Nanoparticles Optoelectronics business Fluorescent Dyes |
| Zdroj: | Chemistry – A European Journal. 27:13085-13091 |
| ISSN: | 1521-3765 0947-6539 |
| Popis: | Fluorophores with emission in the second near-infrared window (NIR-II) have displayed salient advantages for biomedical applications. However, the common strategy of reducing the energy bandgap of fluorophores so as to achieve red-shifted wavelengths always leads to compromised fluorescent brightness. Herein, we propose a molecular design concept of "ring-fusion" to modify the acceptor of AIEgen that can extend the luminous wavelength from NIR-I to NIR-II. The fused-acceptor-containing fluorophore yielded, TTQP, has an enhanced absorption coefficient with a higher brightness in nanoparticle formation compared to its NIR-I emissive counterpart (TTQ-DP) with a non-fused acceptor. Theoretical calculation further confirms that the ring fusion can efficiently promote the rigidity and planarity of the electron-deficient core, leading to a lower reorganization energy and nonradiative decay. The TTQP NPs yielded thus allow sensitive NIR-II fluorescence imaging of vasculature and intestinal inflammation in mice models. Therefore, we anticipate that our work will provide a promising molecular-engineering strategy to enrich the library and broaden the application scope of NIR-II fluorophores. |
| Databáze: | OpenAIRE |
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