Significant enhancement in the efficiency and selectivity of iron-catalyzed oxidative cross-coupling of phenols by fluoroalcohols

Autor:	Aviya Werbeloff, Kavitha Sudheendran, Yulia Vainer, Sachin Narute, Doron Pappo, Hadas Shalit, Eden Gaster, Almog Regev
Rok vydání:	2014
Předmět:	Chemistry Iron catalyzed General Medicine General Chemistry Oxidative phosphorylation Photochemistry Catalysis Coupling (electronics) chemistry.chemical_compound Phenol Organic chemistry Oxidative coupling of methane Phenols Chemoselectivity Selectivity
Zdroj:	Angewandte Chemie (International ed. in English). 54(14)
ISSN:	1521-3773
Popis:	Significant enhancement of both the rate and the chemoselectivity of iron-catalyzed oxidative coupling of phenols can be achieved in fluorinated solvents, such as 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP), 2,2,2-trifluoroethanol (TFE), and 1-phenyl-2,2,2-trifluoroethanol. The generality of this effect was examined for the cross-coupling of phenols with arenes and polycyclic aromatic hydrocarbons (PAHs) and of phenol with β-dicarbonyl compounds. The new conditions were utilized in the synthesis of 2′′′-dehydroxycalodenin B in only four synthetic steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c267f83a36a880d4d242f6a21466529 https://pubmed.ncbi.nlm.nih.gov/25655277 Zobrazit plný text záznamu Plný text