Lipoprotein (a) and vascular disease in diabetic patients
| Autor: | L. Amadio, P. Fumelli, Richard W. James, M. Boemi, D. Pometta, C. Sirolla |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Myocardial Ischemia Disease Gastroenterology Interquartile range Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans Vascular Diseases Risk factor Triglycerides Aged Glycated Hemoglobin Peripheral Vascular Diseases Analysis of Variance biology business.industry Vascular disease Cholesterol HDL Lipoprotein(a) Cholesterol LDL Stepwise regression Middle Aged medicine.disease Endocrinology Cholesterol Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 biology.protein Regression Analysis business Diabetic Angiopathies Lipoprotein |
| Zdroj: | Diabetologia. 38(6) |
| ISSN: | 0012-186X |
| Popis: | In order to assess the potential role of lipoprotein (a) as a risk factor for cardiovascular disease in diabetes mellitus, plasma concentrations were measured in a large group (n = 500) of non-insulin-dependent (NIDDM, n = 355) and insulin-dependent (IDDM, n = 145) patients. Concentrations of lipoprotein (a) were compared in diabetic patients with (n = 153) or without (347) documented vascular disease (ischaemic heart disease, peripheral vascular disease or macroangiopathy). They were significantly higher (p0.05) in patients with ischaemic heart disease (mean [interquartile range] 15.5 (5.0-38.0) vs 9.0 (4.5-26.0) mg/dl) or macroangiopathy (13.0 (5.0-38.0) vs 9.0 (4.0-25.0) mg/dl) compared to patients without manifestations of vascular disease. In addition, stepwise logistic regression analysis identified lipoprotein (a) levelsor = 30 mg/dl as being independently associated with the presence of cardiovascular disease. Lipoprotein (a) was an independent risk factor for ischaemic heart disease and macroangiopathy in this group of IDDM and NIDDM patients. |
| Databáze: | OpenAIRE |
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