Sex differences in associations between blood lipids and cerebral small vessel disease

Autor: Z.-G. Yin, K. Yu, W.-W. Wang, H. Lin, Q.-S. Wang, Z.-H. Yang
Rok vydání: 2018
Předmět:
Brain Infarction
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Blood lipids
Physiology
030204 cardiovascular system & hematology
Severity of Illness Index
03 medical and health sciences
chemistry.chemical_compound
Sex Factors
0302 clinical medicine
High-density lipoprotein
Leukoencephalopathies
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Humans
Prospective Studies
Stroke
Aged
Dyslipidemias
Nutrition and Dietetics
Apolipoprotein A-I
business.industry
Cholesterol
Cholesterol
HDL
Middle Aged
medicine.disease
Lipids
Magnetic Resonance Imaging
Hyperintensity
Cross-Sectional Studies
Endocrinology
chemistry
Cerebral Small Vessel Diseases
Female
lipids (amino acids
peptides
and proteins)
Cardiology and Cardiovascular Medicine
business
Body mass index
Biomarkers
030217 neurology & neurosurgery
Dyslipidemia
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 28:28-34
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2017.10.001
Popis: Background and aims Dyslipidemia predicts higher risk of coronary events and stroke and might be associated with cerebral small vessel disease (SVD). Previous studies linking blood lipids and SVD have yielded inconsistent results, which may be attributable to sex differences in lipids metabolism. The aim of this study was to investigate the relationships between blood lipids and SVD in neurologically healthy men and women. Methods and results Consecutive 817 people aged 50 years or more were enrolled and underwent magnetic resonance imaging scans to evaluate the periventricular white matter lesions (PVWMLs), deep white matter lesions (DWMLs) and silent brain infarction (SBI). Fasting total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol, apolipoprotein A-1 (apoA-1) and apolipoprotein B were assessed. Multivariable logistic regression analyses were performed to determine the associations of blood lipids with PVWMLs, DWMLs and SBI. HDL-C (for PVWMLs: OR 0.36, 95% CI 0.19–0.71; for DWMLs: OR 0.35, 95% CI 0.20–0.63) and apoA-1 (for PVWMLs: OR 0.27, 95% CI 0.11–0.66; for DWMLs: OR 0.22, 95% CI 0.10–0.48) were inversely associated with the severity of PVWMLs and DWMLs in women but not in men after adjustment for age, hypertension, diabetes, current smoking, daily drinking, body mass index and uric acid. Additionally, no blood lipids were significantly associated with SBI. Conclusions Our findings demonstrate that sex differences may exist in the associations between lipids and SVD. HDL-C and apoA-1 levels were inversely associated with the severity of PVWMLs and DWMLs in women.
Databáze: OpenAIRE
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