High-dose ketoconazole treatment in advanced prostatic cancer
| Autor: | I. Tóth, J. Oszlánczy, S. Scultéty, I. Faredin |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Urology Prostate Internal medicine Sex Hormone-Binding Globulin medicine Endocrine system Humans Testosterone Progesterone Aged business.industry Cancer Prostatic Neoplasms Jaundice Middle Aged Androgen medicine.disease medicine.anatomical_structure Endocrinology Ketoconazole Nephrology Androgens medicine.symptom business Carrier Proteins Hormone medicine.drug |
| Zdroj: | International urology and nephrology. 20(4) |
| ISSN: | 0301-1623 |
| Popis: | For purposes of testosterone suppression, high doses of ketoconazole were administered to 18 patients with advanced cancer of the prostate for an average of 6 months. A well-evaluable response was observed both objectively and subjectively. The blood levels of the steroid hormones were measured during the treatment period and it was found that testosterone biosynthesis was blocked. Mild gastrointestinal symptoms occurred in the minority of the cases, and administration of the drug had to be stopped in one case because of jaundice. The possibility of the use of smaller doses is being investigated, which may lead to the development of an alternative to the endocrine treatment methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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