Lowering weight equals reduction of mortality: How far are we from the 'Ithaka' of ideal weight control?
| Autor: | Dimitris Tousoulis, Costas Tsioufis, Kyriakos Dimitriadis |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male business.industry Endocrinology Diabetes and Metabolism Blood Pressure Middle Aged 030204 cardiovascular system & hematology Toxicology Reduction (complexity) 03 medical and health sciences 0302 clinical medicine Ideal weight Hypertension Weight Loss Internal Medicine Humans Medicine Female Self Report 030212 general & internal medicine Mortality Cardiology and Cardiovascular Medicine business Risk Reduction Behavior Body Weight and Mortality |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1751-7176 1524-6175 |
| Popis: | Although weight loss improves blood pressure (BP), its association with mortality remains unclear. In the Trials of Hypertension Prevention (TOHP), individuals aged 30-54 years with high normal BP were randomized to weight loss, usual care or other intervention over 18 months (TOHP I) or 3-4 years (TOHP II), with average 23-year mortality follow-up. We examined mortality and (a) randomized weight loss and (b) observed weight change among all with high baseline weight. Among 2964 randomized participants, 227 deaths occurred, with no intervention difference (hazard ratio (HR) = 0.97, 95% confidence interval (CI) = 0.75-1.26, P = 0.84). Among 3828 high-weight participants, weight change was directly related to mortality (HR = 1.14 per 5% change, 95% CI = 1.02-1.28, P = 0.019). During the trial 15% lost5% (HR = 0.82), 29% lost 0-=5% (HR = 0.94), 41% gained 0-5% (reference), and 16% gained5% (HR = 1.29) (P-trend = 0.046). This is consistent with a long-term beneficial effect of presumed intentional weight loss on mortality. |
| Databáze: | OpenAIRE |
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