Proposing the sweet solution preference test as a screening assay for anti-manic effects of mood stabilizers
| Autor: | Haim Einat, Nirit Z. Kara, Shlomit Flaisher-Grinberg |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Predictive validity Male medicine.medical_specialty Bipolar Disorder Context (language use) Imipramine 03 medical and health sciences Mice 0302 clinical medicine Preference test Antimanic Agents Internal medicine medicine Animals Bipolar disorder Mice Inbred ICR business.industry General Neuroscience food and beverages medicine.disease Mice Inbred C57BL 030104 developmental biology Mood Antidepressant Anticonvulsants medicine.symptom business Mania 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of neuroscience methods. 346 |
| ISSN: | 1872-678X |
| Popis: | Background There is a desperate need for in-vivo behavioral screening tests for anti-manic effects. The frequently used psychostimulant-induced hyperactivity test appears to have lower validity than previously described, but other quick, simple and high throughput tests are currently unavailable. New method In the context of modeling the behavioral facets of mania, we previously suggested that the sweet solution preference test (SSP) in naive mice might have predictive validity for screening anti-manic effects. The current study further examined this proposal by testing the effects of lithium, valproate and imipramine on SSP in three strains of mice (male mice from the black Swiss, ICR and C57bl/6 strains) and an exploratory test in females (black Swiss strain). Results Data demonstrate that lithium and valproate at appropriate dosing schedules significantly and reliably reduce SSP in all three strains (including in females) but that the antidepressant imipramine has no effects. Comparison with existing methods The results support the utilization of the SSP as mice screening model for anti-manic effects of drugs with stronger predictive validity compared with other methods. Conclusions The SSP is not a comprehensive model for bipolar disorder but it has good predictive validity and strong practical value that can be applied towards simple and fast screening of large numbers of animals, without the need for specialized equipment or complicated/prolonged procedures. We therefore propose that the SSP is an advantageous screening assay for testing novel mood stabilizing drugs for anti-manic properties. |
| Databáze: | OpenAIRE |
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