Treatment of intermediate-risk prostate cancer with Cs-131: Long-term results from a single institution
| Autor: | Joshua L. Rodríguez-López, Ryan P. Smith, Ronald M. Benoit, Sushil Beriwal, Ankur K. Patel |
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| Rok vydání: | 2022 |
| Předmět: |
Male
medicine.medical_specialty business.industry medicine.medical_treatment Brachytherapy Urology Prostatic Neoplasms Androgen Antagonists Prostate-Specific Antigen medicine.disease Androgen deprivation therapy Prostate-specific antigen Prostate cancer Oncology Cesium Radioisotopes medicine Humans Radiology Nuclear Medicine and imaging External beam radiotherapy Single institution business Intermediate risk Prostate brachytherapy Follow-Up Studies |
| Zdroj: | Brachytherapy. 21:79-84 |
| ISSN: | 1538-4721 |
| DOI: | 10.1016/j.brachy.2021.08.008 |
| Popis: | To evaluate our institutional outcomes utilizing Cs-131 prostate brachytherapy (PB) for the intermediate-risk (IR) group of prostate cancer patients.We reviewed a prospectively collected database of men treated with Cs-131 PB between 2006 and 2019. Patients with less than 24-months follow-up were excluded. Patients were classified as IR if they had one of the following factors: Gleason Score 7, prostate specific antigen10 but20 ng/mL, or T2b-c on clinical exam. We defined unfavorable-IR (UIR) as having either Grade Group 3,1 IR factors, or ≥50% positive core biopsies. The Kaplan-Meier method was used to estimate actuarial event-time probabilities for biochemical freedom from disease (BFD).A total of 335 patients with a median follow-up of 70.1 months (IQR 48.3-106.3 months) were identified. Androgen deprivation therapy (ADT) was used in 7.2% of patients. Favorable-IR (FIR) patients were commonly treated with PB alone (91.8%). FIR patients who underwent PB alone had a 5-year BFD of 98.1%. UIR patients were commonly treated with external beam radiotherapy plus PB (61.2%). These patients had 5-year BFD of 91.1%. The 5-year BFD for UIR patients treated without ADT was 90.9%, whereas it was 95.0% among UIR patients treated with ADT (log-rank p = 0.83).FIR patients have excellent outcomes when treated with PB alone. External beam radiotherapy plus PB is a reasonable treatment approach for UIR patients. Future studies may elucidate which IR patients would benefit from treatment intensification. |
| Databáze: | OpenAIRE |
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