Early Application of Next-Generation Sequencing Identifies Pancreatic Mass as Metastasis From an EGFR-Mutated Lung Adenocarcinoma
| Autor: | Luxi, Chen, John, Davelaar, Srinivas, Gaddam, Kambiz, Kosari, Nicholas, Nissen, George, Chaux, Christopher, Lee, Eric, Vail, Andrew, Hendifar, Jun, Gong, Karen, Reckamp, Arsen, Osipov |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of the National Comprehensive Cancer Network. 21:6-11 |
| ISSN: | 1540-1413 1540-1405 |
| Popis: | Pancreatic metastasis of primary lung adenocarcinoma is a rare occurrence, accounting for EGFR-mutated lung adenocarcinoma with metastases to the pancreas via early application of next-generation sequencing (NGS). The use of NGS early in the patient’s clinical course not only changed the treatment strategy but also drastically altered the prognosis. Although metastatic pancreatic adenocarcinoma has a poor prognosis and survival rate, treatment of EGFR-mutated non–small cell lung cancer with EGFR tyrosine kinase inhibitors is associated with high response rates. Importantly, our case demonstrates that timely application of NGS very early in the disease course is paramount to the diagnosis, management, and prognosis of solid malignancies. |
| Databáze: | OpenAIRE |
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