Progression to cirrhosis in hepatitis C patients: an age-dependent process
| Autor: | Christian Trepo, Hans L. Tillmann, Pierre Pradat, Nicolas Voirin, Michèle Chevallier |
|---|---|
| Přispěvatelé: | Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Liver Cirrhosis Male [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] Pathology medicine.medical_specialty Cirrhosis Alcohol Drinking Hepatitis C virus Age dependent medicine.disease_cause Gastroenterology Body Mass Index 03 medical and health sciences Therapeutic approach 0302 clinical medicine Older patients Fibrosis Internal medicine Humans Medicine 030212 general & internal medicine Age of Onset Aged 2. Zero hunger Hepatology business.industry Alanine Transaminase Hepatitis C Middle Aged medicine.disease 3. Good health Disease Progression Female 030211 gastroenterology & hepatology business Body mass index |
| Zdroj: | Liver-Copenhagen Liver-Copenhagen-, 2007, 27, pp.335-339 |
| ISSN: | 1478-3231 1478-3223 0106-9543 1600-0676 |
| Popis: | Background: Age at infection is known to be associated with disease progression rate in hepatitis C virus (HCV) infected patients. The aim of this study was to assess when cirrhosis is expected to occur according to host and viral factors. Methods: Fibrosis progression was studied in 247 naive HCV patients using multiple regression analysis. The expected age at cirrhosis was calculated for each patient. Results: Progression rate was 0.13, 0.14, 0.27, and 0.36 U of fibrosis/year for patients with age at infection ≤19, 20–24, 25–36 and ≥37 years, respectively. Age at infection above 37 years was independently associated with fast progression (rate>0.13; P=0.001). Body mass index >25 kg/m2 and alanine aminotransferase>3 × ULN are also possibly associated with faster progression. Based on progression rates, the expected age at cirrhosis is 65.4, 64.6, 64.8 and 69.4 years for age at infection ≤19, 20–24, 25–36, ≥37 years, respectively. Conclusion: Most HCV patients, if untreated, are expected to develop cirrhosis at about 65 years, irrespective of the age at infection. Thus, age itself seems even more important than age at infection for predicting the occurrence of liver cirrhosis. A specific active monitoring and therapeutic approach should be adopted in older patients to prevent progression to cirrhosis and its complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|