Next Generation Sequencing for liquid biopsy based testing in Non-Small Cell Lung Cancer in 2021
| Autor: | Francesco Pepe, Gianluca Russo, Antonino Iaccarino, Gianluca Gragnano, José Luis Costa, Alessandro Russo, Luca Quagliata, María José Serrano, Christian Rolfo, Umberto Malapelle, Diego de Miguel-Pérez, Valeria Denninghoff, Pasquale Pisapia |
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| Přispěvatelé: | Pisapia, Pasquale, Costa, José Lui, Pepe, Francesco, Russo, Gianluca, Gragnano, Gianluca, Russo, Alessandro, Iaccarino, Antonino, de Miguel-Perez, Diego, Serrano, Maria Josè, Denninghoff, Valeria, Quagliata, Luca, Rolfo, Christian, Malapelle, Umberto |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Lung Neoplasms Context (language use) NSCLC DNA sequencing 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma Non-Small-Cell Lung Biomarkers Tumor Medicine Humans Liquid biopsy Lung cancer early detection liquid biopsy business.industry Molecular pathology screening Advanced stage Cancer High-Throughput Nucleotide Sequencing Hematology medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis NGS Non small cell business |
| Popis: | Lung cancer is the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) representing its most commonly diagnosed sub-type. Despite the significant improvements in lung cancer biomarkers knowledge, accompanied by substantial technological advances in molecular tumor profiling, a considerable fraction (up to 30 %) of advanced NSCLC patient presents with major testing challenges or tissue unavailability for molecular analysis. In this context, liquid biopsy is on the rise, currently gaining considerable interest within the molecular pathology and oncology community. Molecular profiling of liquid biopsy specimens using next generation molecular biology methodologies is a rapidly evolving field with promising applications not exclusively limited to advanced stages but also more recently expanding to early stages cancer patients. Here, we offer an overview of some of the most consolidated and emerging applications of next generation sequencing technologies for liquid biopsy testing in NSCLC. |
| Databáze: | OpenAIRE |
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