Performance of a household tuberculosis exposure survey among children in a Latin American setting
| Autor: | Molly F. Franke, Milagros Mendoza, H Marin, C Pinedo, Julia Coit, Leonid Lecca, Silvia S. Chiang |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Male Latin Americans Tuberculosis Adolescent 030106 microbiology Tuberculin Article 03 medical and health sciences 0302 clinical medicine Tuberculosis diagnosis Environmental health Surveys and Questionnaires Peru Medicine Humans Mass Screening 030212 general & internal medicine Child Family Characteristics business.industry Extramural Tuberculin Test Infant Newborn Infant Odds ratio TUBERCULOSIS EXPOSURE Environmental Exposure medicine.disease Preventive therapy Infectious Diseases Child Preschool Regression Analysis Female business psychological phenomena and processes |
| Zdroj: | Int J Tuberc Lung Dis |
| ISSN: | 1815-7920 |
| Popis: | OBJECTIVE: To evaluate the performance of a survey that quantifies the intensity of household tuberculosis (TB) exposure among children.METHODS: Children aged 0–14 years in Lima, Peru, with ≥1 signs and/or symptoms of TB and a history of contact with an adult TB patient were included. The 10-question survey was administered to caregivers and addressed sleep proximity, frequency of exposure, and infectiousness of the contact. Infection status was determined using tuberculin skin tests (TSTs). The exposure scale was evaluated for association with TST positivity using mixed-effects regression analyses.RESULTS: The exposure score was significantly associated with TST positivity (age-adjusted odds ratio [aOR] 1.14, 95%CI 1.02–1.28). We observed a stronger association with TST positivity in children aged ≤5 years; (aOR 1.23, 95%CI 1.07–1.41) and no association in children 6–14 years of age (aOR 0.99, 95%CI 0.82–1.20).CONCLUSION: This survey was easy to use and modestly successful in predicting TST positivity in children aged ≤5 years. It may be a useful resource for clinicians for diagnosing TB in children, and for national TB programs aiming to scale up preventive therapy initiatives. |
| Databáze: | OpenAIRE |
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