The basophil activation test reflects the severity and the threshold of allergic reactions to peanut – a double-blind-placebo-controlled peanut challenge study

Autor:	Gideon Lack, Victor Turcanu, Abdel Douiri, Suzana Radulovic, Alick Stephens, Alexandra F. Santos, George Du Toit
Jazyk:	angličtina
Předmět:	Pulmonary and Respiratory Medicine Allergy CD63 business.industry Immunology Peanut allergy food and beverages Basophil medicine.disease Placebo Basophil activation medicine.anatomical_structure Oral allergy syndrome Poster Presentation medicine Immunology and Allergy business Anaphylaxis
Zdroj:	Clinical and Translational Allergy
ISSN:	2045-7022
DOI:	10.1186/2045-7022-5-s3-p25
Popis:	Results 44 peanut allergic children (median age 5 years) reacted to peanut on DBPCPC with clinical symptoms than ranged from oral allergy syndrome to anaphylaxis. 61% of patients reacted to 0.1g of peanut protein. The mean %CD63+ basophil at 10 and 100 ng/ml of PE was independently associated with severity (p=0.012) whilst CD-sens (1/EC50x100) was independently associated with threshold (p=0.039) of allergic reactions to peanut. Severity and threshold parameters were correlated both at the clinical (Rs=-0.38; p=0.013) and at the basophil level (Rs=0.65; p
Databáze:	OpenAIRE
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