Engineering natural matrices with black phosphorus nanosheets to generate multi-functional therapeutic nanocomposite hydrogels
| Autor: | Xuetao Shi, Yali Miao, Xiao Liu, Yingjun Wang, Lijing Hao, Yunhua Chen, Qingtao Li, Lei Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Bone Regeneration
Materials science Biocompatibility Biomedical Engineering Mice Nude Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Nanocomposites Rats Sprague-Dawley Tissue engineering Osteogenesis Cell Line Tumor Animals Humans General Materials Science Bone regeneration Nanosheet Nanocomposite Tissue Engineering technology industry and agriculture Hydrogels Mesenchymal Stem Cells Phosphorus Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences Self-healing hydrogels Surface modification 0210 nano-technology |
| Zdroj: | Biomaterials Science. 7:4046-4059 |
| ISSN: | 2047-4849 2047-4830 |
| DOI: | 10.1039/c9bm01072f |
| Popis: | Natural polysaccharides and proteins have been widely explored for the preparation of hydrogel matrices due to their promising biocompatibility and biodegradability. However, it is challenging to achieve multiple functions of the hydrophilic matrix through convenient functionalization strategies. Herein we report the facile engineering of a natural matrix with black phosphorus (BP) nanosheets as building blocks to generate a therapeutic nanocomposite hydrogel (BP/Gel) with an array of promising features. BP nanosheets could reinforce the crosslinking networks and significantly promote their capabilities of mineralization. The BP/Gel nanocomposite hydrogel exhibits excellent near infrared (NIR) photothermal performance and good biocompatibility in vitro and in vivo. Upon NIR irradiation, the nanocomposite hydrogel demonstrates efficient photothermal antibacterial features. More remarkably, the BP nanosheet engineered hydrogel matrix is capable of promoting in vitro osteogenesis in the absence of osteoinductive factors, and in the meantime demonstrates significant newborn cranial bone tissue formation in a Sprague-Dawley rat model. These results demonstrate that BP nanosheets could endow the natural matrix with multiple functions including reinforced networks, photothermal performance, enhanced mineralization and bone regeneration, which provides a facile and highly efficient therapeutic strategy for bone tissue engineering. |
| Databáze: | OpenAIRE |
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