Low Postoperative Platelet Counts Are Associated with Major Morbidity and Inferior Survival in Adult Recipients of Orthotopic Liver Transplantation
| Autor: | Jelena von der Massen, Joerg Boecker, I. Amygdalos, Pavel Strnad, Wen-Jia Liu, F. Meister, Zoltan Czigany, Georg Lurje, Ulf P. Neumann, Daniel Antonio Morales Santana, Jan Bednarsch |
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| Přispěvatelé: | Surgery, RS: FHML non-thematic output |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
IMPACT Orthotopic liver transplantation (OLT) Youden's J statistic Platelet counts Logistic regression Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine TRANSFUSION law Internal medicine Medicine FAILURE Mortality INDEX Receiver operating characteristic business.industry Proportional hazards model THROMBOCYTOPENIA Odds ratio Intensive care unit Confidence interval 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Morbidity business Complication |
| Zdroj: | Journal of Gastrointestinal Surgery, 24(9), 1996-2007. Springer Verlag |
| ISSN: | 1091-255X |
| Popis: | BACKGROUND: Platelets (PLT) play an essential functional role in cellular injury and liver regeneration following partial hepatectomy and orthotopic liver transplantation (OLT). Here, we investigated the association of postoperative PLT counts with short- and long-term outcomes in adult OLT recipients.METHODS: Three hundred consecutive patients from our prospective OLT database were analyzed retrospectively (May 2010-November 2017). Ninety-day post-OLT complications were graded using the Clavien-Dindo (CD) classification and quantified by the comprehensive complication index (CCI). To determine the prognostic accuracy of PLT counts, the area under the receiver operating characteristic curve (AUROC) was calculated for major complications (CD ≥ 3b). Parametric and non-parametric tests were applied for subgroup analyses. Uni- and multivariable logistic regression analyses were performed to identify risk factors for major complications. Graft and patient survival were analyzed using the Kaplan-Meier method as well as uni- and multivariable Cox regression analyses.RESULTS: Postoperative day 6 PLT counts CONCLUSION: In OLT patients, a PLT count on POD6 of less than 70 × 109/L bears a prognostic significance warranting further investigations. |
| Databáze: | OpenAIRE |
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