Comparison of nerve conduction velocity distribution methods by cold exposure and ischemia
| Autor: | Nazmi Yaras, Hilmi Uysal, Kamil Savaş |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Materials science Conduction velocity distribution Neural Conduction Cold exposure Ischemia Action Potentials Nerve conduction velocity 03 medical and health sciences 0302 clinical medicine Peripheral nerve Internal medicine medicine Animals Distribution (pharmacology) Peripheral Nerves General Neuroscience Neurosciences General Medicine medicine.disease Rats Compound muscle action potential Cold Temperature Disease Models Animal 030104 developmental biology Cardiology 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Neuroscience. 132:13-22 |
| ISSN: | 1543-5245 0020-7454 |
| Popis: | Non-invasive estimation of the conduction velocity distribution (CVD) of a peripheral nerve has the potential to both improve clinical diagnoses of pathology and to observe the progress of the disease or the efficacy of treatments. Comparisons were made of the performance of three non-invasive CVD estimation methods proposed by independent research groups on peripheral nerve bundles under different conditions.The first method (Cummins) uses a nerve compound action potential (CAP) with temporal dispersion and a mathematical single fiber action potential (SFAP). The second method (Barker) uses two CAPs and a non-mathematical SFAP waveform. The third method (Hirose) uses two CAPs recorded from distal and proximal sites. The Cummins and Barker methods have iterative solutions in the time domain while the Hirose method is a deconvolution estimator in the frequency domain. In order to compare these methods, we used cold exposure to affect primarily motor fibers and ischemia to affect primarily sensory fibers on rat caudal nerve bundles.The Cummins method is sensitive to changes in motor and sensory fiber percentages in CVD if it is used with the volume conductor model. The Barker and Hirose methods are sensitive to motor fiber percentages in CVD but they cannot detect changes in sensory fiber percentages accurately.Estimation of the CVD using a priori SFAP created with a volume conductor model can non-invasively supply accurate and precise information about fiber groups in a peripheral nerve bundle. |
| Databáze: | OpenAIRE |
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