Resting extracellular signal-regulated protein kinase 1/2 expression following a continuum of chronic resistance exercise training paradigms
| Autor: | Donald B. Thomason, Justin X. Nicoll, Christopher A. Moore, Andrew C. Fry, Brian K. Schilling, Andrew J. Galpin |
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| Rok vydání: | 2016 |
| Předmět: |
MAPK/ERK pathway
Adult Male medicine.medical_specialty Anabolism Weight Lifting Strength training sports Biopsy Down-Regulation Physical Therapy Sports Therapy and Rehabilitation Biology Quadriceps Muscle 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Humans Orthopedics and Sports Medicine Protein kinase A Circuit training Mitogen-Activated Protein Kinase 1 Kinase Resistance training Skeletal muscle Resistance Training 030229 sport sciences Endocrinology medicine.anatomical_structure sports.sport Physical therapy Circuit-Based Exercise 030217 neurology & neurosurgery Physical Conditioning Human |
| Zdroj: | Research in sports medicine (Print). 24(3) |
| ISSN: | 1543-8635 |
| Popis: | Extracellular signal-regulated protein kinase 1/2 (ERK1/2) moderates skeletal muscle growth; however, chronic responses of this protein to unique resistance exercise (RE) paradigms are yet to be explored. The purpose of this investigation was to describe the long-term response of ERK1/2 following circuit weight training (CWT), recreationally weight training (WT), powerlifting (PL) and weightlifting (WL). Independent t-tests were used to determine differences in trained groups compared to sedentary controls. Total ERK1/2 content was lower in PL and WL compared to their controls (p ≤ 0.05). Specific trained groups displayed large (WL: pERK/total-ERK; d = 1.25) and moderate (CWT: total ERK1/2; d = 0.54) effect sizes for altered kinase expression compared to controls. The results indicate ERK1/2 expression is down-regulated after chronic RE in well-trained weightlifters and powerlifters. Lower expression of this protein may be a method in which anabolism is tightly regulated after many years of high-intensity RE. |
| Databáze: | OpenAIRE |
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