In vitro potentiation of the activity of synthetic ovine corticotropin-releasing factor by arginine vasopressin
| Autor: | Jaw-Kang Chang, D. Chang, C.R. Thomas, M. Shimizu, Akira Arimura, C.M. Turkelson |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
endocrine system Vasopressin medicine.medical_specialty Arginine Physiology Corticotropin-Releasing Hormone Biochemistry Cellular and Molecular Neuroscience Endocrinology Anterior pituitary Adrenocorticotropic Hormone Internal medicine medicine Animals Arginine vasopressin receptor 1B Sheep urogenital system Chemistry Long-term potentiation Drug Synergism In vitro Rats Arginine Vasopressin medicine.anatomical_structure Ovine corticotropin-releasing factor Pituitary Gland hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 3(2) |
| ISSN: | 0196-9781 |
| Popis: | The ability of arginine vasopressin (AVP) to potentiate the actions of synthetic ovine corticotropin-releasing factor (CRF) was examined using anterior pituitary fragments. Marked potentiation of ACTH release was observed upon incubating the fragments with a combination of 2 nM AVP and 1 nM CRF. Potentiation of CRF-induced ACTH release was also observed when the fragments were incubated with a combination of 1 nM AVP and 0.5 nM CRF. These results suggest that AVP may play a role in the release of ACTH from the adenohypophysis. |
| Databáze: | OpenAIRE |
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