| Autor: |
Florian, Seckler, Célia, Turco, Kayvan, Mohkam, Pietro, Addeo, Fabien, Robin, François, Cauchy, Charlotte, Maulat, Raffaele, Brustia, Brice, Paquette, François, Faitot, Delphine, Weil Verhoeven, Anne, Minello, Zaher, Lakkis, Vincent, Di Martino, Marianne, Latournerie, Laurence, Chiche, Mehdi, El Amrani, Petru, Bucur, Francis, Navarro, Sophie, Chopinet, Mircea, Chirica, Johan, Gagnière, Antonio, Iannelli, Gaëlle, Cheisson, Christophe, Chardot, Daniele, Sommacale, Fabrice, Muscari, Federica, Dondero, Laurent, Sulpice, Philippe, Bachellier, Olivier, Scatton, Jean Yves, Mabrut, Bruno, Heyd, Alexandre, Doussot |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Transplantation. 107:664-669 |
| ISSN: |
0041-1337 |
| Popis: |
In the current setting of organ shortage, brain-dead liver donors with recent liver trauma (RLT) represent a potential pool of donors. Yet, data on feasibility and safety of liver transplantation (LT) using grafts with RLT are lacking.All liver grafts from brain-dead donors with RLT proposed for LT between 2010 and 2018 were identified from the nationwide CRISTAL registry of the Biomedicine Agency. The current study aimed at evaluating 1-y survival as the primary endpoint.Among 11 073 LTs, 142 LTs (1.3%) using grafts with RLT were performed. These 142 LTs, including 23 split LTs, were performed from 131 donors (46.1%) of 284 donors with RLT proposed for LT. Transplanted grafts were procured from donors with lower liver enzymes levels (P 0.001) and less advanced liver trauma according to the American Association for the Surgery of Trauma liver grading system (P 0.001) compared with not transplanted grafts. Before allocation procedures, 20 (7%) of 284 donors underwent damage control intervention. During transplantation, specific liver trauma management was needed in 19 patients (13%), consisting of local hemostatic control (n = 15), partial hepatic resection on back-table (n = 3), or perihepatic packing (n = 1). Ninety-day mortality and severe morbidity rates were 8.5% (n = 12) and 29.5% (n = 42), respectively. One-year overall and graft survival rates were 85% and 81%, and corresponding 5-y rates were 77% and 72%, respectively.Using liver grafts from donors with RLT seems safe with acceptable long-term outcomes. All brain-dead patients with multiorgan trauma, including liver injury, should be considered for organ allocation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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