The role of ischemic preconditioning and pentoxifylline in intestinal ischemia/reperfusion injury of rats
| Autor: | Geraldo Ferreira de Oliveira, Eduardo Hiroshi Tikazawa, Hugo P. Monteiro, Djalma José Fagundes, Murched Omar Taha, Teresinha Regina Ribeiro de Oliveira, Ricardo Simoes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
endocrine system RD1-811 medicine.medical_treatment Vasodilator Agents Ischemia complex mixtures Pentoxifylline 03 medical and health sciences 0302 clinical medicine Intestinal mucosa medicine.artery parasitic diseases medicine Animals Superior mesenteric artery cardiovascular diseases Rats Wistar Ischemic Preconditioning Saline Intestinal ischemia business.industry medicine.disease Rats Intestines Disease Models Animal 030220 oncology & carcinogenesis Anesthesia Reperfusion Injury Ischemic preconditioning 030211 gastroenterology & hepatology Surgery business Reperfusion injury medicine.drug |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP Acta Cirurgica Brasileira, Vol 32, Iss 7, Pp 559-567 (2017) Acta Cirúrgica Brasileira v.32 n.7 2017 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 32, Issue: 7, Pages: 559-567, Published: JUL 2017 |
| Popis: | UFGD, Ministerio da Educacao do Brasil Purpose: To investigate the role of ischemic preconditioning (IPC) and pentoxifylline (PTX) in intestinal mucosa ischemia/reperfusion injury (IR). Methods: Thirty rats were assigned to 5 groups (N= 6): (CG): no clamping of the superior mesenteric artery (90 min.) (IR-SS): saline + ischemia (30 min.) + reperfusion (60 min.) (IRPTX): PTX + ischemia (30min.) + reperfusion (60 min.) (IPC-IR-SS): 5 min. of ischemia + 5 minutes of reperfusion (IPC) + saline + ischemia (30 min.) + reperfusion (60 min.) (IPC-IR-PTX): 5 min. of ischemia + 5 min. of reperfusion (IPC) + PTX + 30 min. of I + 60 minutes of R. Results: The IR-PTX, IPC-IR-SS and IPC-IR-PTX groups had significantly lower scores of mucosa damage than the IR-SS group. IR-PTX group showed higher scores than the IPC-IR-PTX group, in accordance with the hypothesis of a favorable effect of IPC alone or in association with PTX. Additionally, IPC-IR-SS had a higher damage score than the IPC-IR-PTX. The villi height and crypt depth were similar in all groups. The villi height in the IR-SS was significantly lower. Conclusion: Ischemic preconditioning or pentoxifylline alone protect the intestinal mucosa from ischemia/reperfusion injury. However, they do not have a synergistic effect when applied together. UFGD, Sch Hlth Sci, Dourados, MS, Brazil Univ Sao Paulo UNIFESP, Dept Morfol & Genet, Sao Paulo, SP, Brazil Univ Estadual Campinas UNICAMP, Sch Med, Dept Publ Hlth, Publ Hlth, Campinas, SP, Brazil Univ Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, Brazil Univ Fed Sao Paulo UNIFESP, Dept Surg, Div Surg Tech & Expt Surg, Sao Paulo, SP, Brazil Univ Sao Paulo UNIFESP, Dept Morfol & Genet, Sao Paulo, SP, Brazil Univ Fed Sao Paulo, Dept Biochem, Sao Paulo, SP, Brazil Univ Fed Sao Paulo UNIFESP, Dept Surg, Div Surg Tech & Expt Surg, Sao Paulo, SP, Brazil UFGD, Ministerio da Educacao do Brasil Web of Science |
| Databáze: | OpenAIRE |
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