Microencapsulated Dopamine (DA)-Induced Restitution of Function in 6-OHDA-Denervated Rat Striatumin vivo: Comparison Between Two Microsphere Excipients
| Autor: | Thomas R. Tice, Lynn Dillon, David W. Mason, Stephan Hjorth, A. McRae |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Apomorphine Dopamine Drug Compounding Central nervous system Excipient Motor Activity Pharmacology Article Excipients chemistry.chemical_compound In vivo medicine Animals Oxidopamine Polyglactin 910 Drug Implants Lactide Rats Inbred Strains Denervation Corpus Striatum Microspheres Rats medicine.anatomical_structure Neurology chemistry Drug delivery Neurology (clinical) medicine.drug |
| Zdroj: | Journal of Neural Transplantation & Plasticity |
| ISSN: | 0792-8483 |
| Popis: | Biodegradable controlled-release microsphere systems made with the biocompatible biodegradable polyester excipient poly [DL lactide-co-glycolide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microspheres encapsulated within two different polymer excipients into denervated- striatal tissue assures a prolonged release of the transmitterin vivo. Moreover, in this regard, the results show that there were clear cut temporal differences in the effect of the two DA microsphere formulations compared in this study, probably reflecting variations in the actual composition (i.e., lactide to glycolide ratio) of the two copolymer excipients examined. This technology has considerable potential for basic research with possible clinical application. |
| Databáze: | OpenAIRE |
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