Antioxidant lignans and chromone glycosides from Eurya japonica
| Autor: | Li Ming Yang Kuo, Susan L. Morris-Natschke, Hsiu O. Ho, Zhi Hu Lin, Yao-Haur Kuo, Kuo Hsiung Lee, Hung Tse Huang, Li Jie Zhang, Chia Ching Liaw, Hui Ling Cheng |
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| Rok vydání: | 2013 |
| Předmět: |
Circular dichroism
Antioxidant Stereochemistry medicine.medical_treatment Theaceae alpha-Tocopherol Taiwan Pharmaceutical Science Positive control Nitric Oxide Antioxidants Lignans Analytical Chemistry chemistry.chemical_compound Picrates Drug Discovery medicine Organic chemistry Eurya japonica Glycosides Nuclear Magnetic Resonance Biomolecular Pharmacology chemistry.chemical_classification biology Molecular Structure Plant Stems Organic Chemistry Biphenyl Compounds Glycoside Stereoisomerism biology.organism_classification Complementary and alternative medicine chemistry Chromones Chromone Molecular Medicine Eusiderin Quercetin Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of natural products. 76(4) |
| ISSN: | 1520-6025 |
| Popis: | Four new 8,8',7,2'-lignans, (+)-ovafolinin B-9'-O-β-d-glucopyranoside (1), (-)-ovafolinin B-9'-O-β-d-glucopyranoside (2), (+)-ovafolinin E-9'-O-β-d-glucopyranoside (3), and (-)-ovafolinin E-9'-O-β-d-glucopyranoside (4), two neolignans, eusiderin N (5) and (7S,8R)-3,5,5'-trimethoxy-4',7-epoxy-8,3'-neolignan-9,9'-diol-4-O-β-d-xylopyranoside (6), and two new chromone glycosides, 5,7-dihydroxy-4H-chromen-4-one-3-O-β-d-glucopyranoside (7) and 5,7-dihydroxy-4H-chromen-4-one-3-O-β-d-xylopyranoside (8), together with 25 known compounds, were isolated from the stems of Eurya japonica. Structural elucidation of compounds 1-8 was established by spectroscopic methods, especially 2D NMR techniques, electronic circular dichroism data, and comparison with reported data. The isolates were evaluated for antioxidant and anti-NO production activities. Compounds 1, 2, 12-20, and 29 (ED50 23.40 μM for 1) demonstrated potent antioxidant activity compared to the positive control α-tocopherol (ED50 27.21 μM). On the other hand, compounds 1, 2, 7-9, 12-20, and 32 showed only weak anti-NO production activity when compared to the positive control quercetin. |
| Databáze: | OpenAIRE |
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