Clinical features and successful recovery from disseminated nocardiosis after BMT
| Autor: | M. C. A. Macedo, A C M Silva, C M Massumoto, Jussara Bianchi Castelli, Frederico Luiz Dulley, M. Ostronoff, Dalton de Alencar Fischer Chamone, E Zambon, Clarisse Martins Machado |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Sulfamethoxazole medicine.medical_treatment Anti-Infective Agents Urinary Graft vs Host Disease Nocardia Infections Lung biopsy Nocardia Trimethoprim medicine Humans Brain abscess Bone Marrow Transplantation Transplantation Chemotherapy business.industry Nocardiosis Hematology Middle Aged medicine.disease Surgery Anti-Bacterial Agents surgical procedures operative Actinomycosis Complication business Immunosuppressive Agents medicine.drug |
| Zdroj: | Bone marrow transplantation. 19(1) |
| ISSN: | 0268-3369 |
| Popis: | Nocardiosis has rarely been described after BMT. When the doses of immunosuppressive therapy were tapered, a 46-year-old BMT recipient developed chronic graft-versus-host disease (GVHD) and immunosuppressive drugs were increased. Sixteen days later the patient developed nocardiosis diagnosed by lung biopsy. Trimethoprim/sulfamethoxazole (TMP/SMZ) was initiated but the doses were reduced because of rising creatinine levels. Skin and cerebral dissemination of nocardiosis was observed and TMP/SMZ doses were increased. After 4 months, the brain lesion was unaltered despite resolution of pulmonary lesions. Clinical improvement was observed after drainage of the brain abscess. |
| Databáze: | OpenAIRE |
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