Hypotension and thirst in rats after isoproterenol treatment
| Autor: | Jean A. Hosutt, Edward M. Stricker, Neil Rowland |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Carbachol Time Factors Drinking Behavior Experimental and Cognitive Psychology Blood Pressure Nephrectomy Thirst Behavioral Neuroscience Dipsogen Internal medicine Renin–angiotensin system medicine Animals Drug Interactions business.industry Angiotensin II Isoproterenol Rats Blood pressure Epinephrine Endocrinology Arterial blood medicine.symptom business medicine.drug |
| Zdroj: | Physiologybehavior. 21(4) |
| ISSN: | 0031-9384 |
| Popis: | Drinking induced in rats by systemic isoproterenol treatment is markedly attenuated after bilateral nephrectomy. The present experiments demonstrate that the hypotension produced by iso-proterenol treatment was more profound, and lasted much longer, in nephrectomized rats than in intact animals. When arterial blood pressure was partially elevated by central administration of angiotensin II or carbachol (Experiment 1) or by intraarterial infusion of epinephrine (Experiment 2), drinking behavior was restored in the nephrectomized animals and their water intakes approximated the amounts consumed by intact rats given isoproterenol. In general, an inverted U-shaped curve was found to define the relation between blood pressure and water intake in rats after isoproterenol treatment. Drinking was most probable when mean arterial blood pressures were in the range of 70–85 mm Hg, whereas rats were unlikely to drink when blood pressures were much below or above this range. These findings indicate that isoproterenol-induced thirst is not dependent on a renal dipsogen, and suggest instead that the hypersecretion of renin that occurs in intact rats is simply permissive of drinking behavior by modulating the hypotensive effects of the drug treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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