Prognostic factors and survival in Ewing's sarcoma treated by limb salvage surgery
| Autor: | L. Trullols-Tarragó, C Lamas-Gomez, A. Peiró-Ibáñez, I. Gracia-Alegría, J Alvarez-SanNicolas |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Bone Neoplasms Kaplan-Meier Estimate Sarcoma Ewing Bone Sarcoma Metastasis 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Humans Adverse effect Retrospective Studies Univariate analysis Chemotherapy Analysis of Variance business.industry Ewing's sarcoma Multimodal therapy General Medicine Middle Aged medicine.disease Limb Salvage Prognosis Progression-Free Survival 030104 developmental biology 030220 oncology & carcinogenesis Female Sarcoma Neoplasm Recurrence Local business |
| Zdroj: | Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 21(10) |
| ISSN: | 1699-3055 |
| Popis: | Survival in Ewing’s sarcoma (ES) has increased with the use of chemotherapy. Surgical techniques such as limb salvage (LS) have been developed. Survival and adverse events have been widely studied in general series of ES, but there are few specific series of ES cases treated by LS, despite this being the most commonly used (surgical) approach. The aim of this study was to determine survival and prognostic factors in ES patients undergoing LS. We analysed all ES patients treated between January 1984 and May 2008 and selected all those treated by systemic multimodal therapy and LS. We assessed the influence of patient characteristics, tumour parameters and therapeutic results in event-free survival (EFS). Ninety patients were included. Fifty of them were treated by systemic multimodal therapy and locally by LS. ean age was 20 years. Overall survival (OS) was 68.8% and EFS was 60.6% at years. In the univariate analysis, pelvic location, age and response to chemotherapy were associated with poor prognosis. After multivariate analysis, poor response to treatment, pelvis location and age between 12 and 17 years were found to be independent prognostic factors. Dissemination at diagnosis was not a prognostic factor. OS and EFS in ES treated by LS were similar to findings in previous ES studies. factors are no different, except for the presence of metastasis at diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink