| Autor: |
Beth Williamson, Lindsay McMurray, Scott Boyd, Olga Collingwood, Neville McLean, Jon Winter-Holt, Christina Chan, Aixiang Xue, William McCoull |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Molecular pharmaceutics. 19(7) |
| ISSN: |
1543-8392 |
| Popis: |
For most oral small-molecule projects within drug discovery, the extent and duration of the effect are influenced by the total clearance of the compound; hence, designing compounds with low clearance remains a key focus to help enable sufficient protein target engagement. Comprehensive understanding and accurate prediction of animal clearance and pharmacokinetics provides confidence that the same can be observed for human. During a MERTK inhibitor lead optimization project, a series containing a biphenyl ring system with benzylamine |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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