Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy
| Autor: | Jacky Wing Yip Lam, Hequn Zhang, Dingwei Xue, Nuernisha Alifu, Abudureheman Zebibula, Chaowei Sun, Xiaoming Yu, Ji Qi, Jun Qian, Ben Zhong Tang, Gonghui Li |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Fluorescence-lifetime imaging microscopy Materials science Infrared Rays Mice Nude General Physics and Astronomy Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Theranostic Nanomedicine Mice In vivo Animals Humans General Materials Science Aggregation-induced emission Cell Proliferation Fluorescent Dyes Mice Inbred ICR Optical Imaging Near-infrared spectroscopy technology industry and agriculture General Engineering Neoplasms Experimental Phototherapy Photothermal therapy 021001 nanoscience & nanotechnology Fluorescence 0104 chemical sciences SUBCUTANEOUS TUMOR Urinary Bladder Neoplasms Cell Tracking Nanoparticles Drug Screening Assays Antitumor 0210 nano-technology |
| Zdroj: | ACS Nano. 12:11282-11293 |
| ISSN: | 1936-086X 1936-0851 1000-1700 |
| Popis: | Second near-infrared (NIR-II, 1000-1700 nm) fluorescence bioimaging has attracted tremendous scientific interest and already been used in many biomedical studies. However, reports on organic NIR-II fluorescent probes for in vivo photoinduced imaging and simultaneous therapy, as well as the long-term tracing of specific biological objects, are still very rare. Herein we designed a single-molecular and NIR-II-emissive theranostic system by encapsulating a kind of aggregation-induced emission luminogen (AIEgen, named BPN-BBTD) with amphiphilic polymer. The ultra-stable BPN-BBTD nanoparticles were employed for the NIR-II fluorescence imaging and photothermal therapy of bladder tumors in vivo. The 785 nm excitation triggered photothermal therapy could completely eradicate the subcutaneous tumor and inhibit the growth of orthotopic tumors. Furthermore, BPN-BBTD nanoparticles were capable of monitoring subcutaneous and orthotopic tumors for a long time (32 days). Single-molecular and NIR-II-emitted aggregation-induced emission nanoparticles hold potential for the diagnosis, precise treatment, and metastasis monitoring of tumors in the future. |
| Databáze: | OpenAIRE |
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