Gastric Parietal Cell Antibodies, Helicobacter Pylori Infection, and Chronic Atrophic Gastritis: Evidence from a Large Population-based Study in Germany
Autor: | Yan Zhang, Ben Schöttker, Dietrich Rothenbacher, Melanie N. Weck, Hermann Brenner |
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Rok vydání: | 2013 |
Předmět: |
Gastritis
Atrophic Male Epidemiology Atrophic gastritis Autoimmune Gastritis Population Helicobacter Infections Parietal Cells Gastric Germany Pepsinogen A Surveys and Questionnaires Pepsinogen C medicine Humans CagA education Aged Parietal cell education.field_of_study biology business.industry Odds ratio Middle Aged medicine.disease Antibodies Bacterial medicine.anatomical_structure Oncology Immunology Disease Progression biology.protein Female Gastritis medicine.symptom Antibody business |
Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 22:821-826 |
ISSN: | 1538-7755 1055-9965 |
DOI: | 10.1158/1055-9965.epi-12-1343 |
Popis: | Background: Striking similarities between autoimmune gastritis and Helicobacter Pylori (H. pylori)-associated gastritis have suggested a potential link between these two pathologic conditions in the progression of chronic atrophic gastritis (CAG); however, evidence has remained conflicting. Methods: Serum pepsinogen I and II, and antibodies against H. pylori in general, the cytotoxin-associated gene A protein (CagA) and parietal cells were measured by ELISA in 9,684 subjects aged 50 to 74 years. Antigastric parietal cell antibody (APCA) prevalence was examined in the overall population and according to sex, age, and H. pylori serostatus. The association between APCA prevalence and CAG was assessed by logistic regression, overall and according to H. pylori status, controlling for potential confounding factors. Results: Overall APCA prevalence was 19.5%. APCA prevalence was strongly associated with CAG, and the association was increasing with increasing severity of CAG. Furthermore, the association between APCA and CAG was even stronger among H. pylori-negative subjects [odds ratio (OR) = 11.3; 95% confidence interval (CI): 7.5–17.1)] than among H. pylori-positive subjects (OR = 2.6; 95% CI: 2.1–3.3). Conclusions: APCA may play a role on the development of gastric atrophy, irrespective of H. pylori infection. Impact: Assessment of APCA might be a useful complement to established markers (such as pepsinogens and H. pylori antibodies) in screening for CAG. Cancer Epidemiol Biomarkers Prev; 22(5); 821–6. ©2013 AACR. |
Databáze: | OpenAIRE |
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