Results of Intradermal Skin Testing with Cefazolin according to a History of Hypersensitivity to Antibiotics
Autor: | Sae Hoon Kim, Min Suk Yang, Sang Heon Cho, Woo-Jung Song, Jae-Woo Kwon, Yoon-Seok Chang, Yoon Jeong Kim |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Hypersensitivity
Immediate Allergy medicine.medical_specialty Intradermal skin testing medicine.drug_class Antibiotics Cephalosporin Cefazolin Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Immunology Allergic Disorders & Rheumatology polycyclic compounds Medicine Humans 030212 general & internal medicine Prospective cohort study Skin Tests business.industry Medical record General Medicine biochemical phenomena metabolism and nutrition Intradermal Tests medicine.disease Dermatology Cephalosporins Negative Skin Test Original Article business medicine.drug |
Zdroj: | Journal of Korean Medical Science |
ISSN: | 1598-6357 1011-8934 |
Popis: | Background The relationship between cephalosporin hypersensitivity and a history of β-lactam hypersensitivity is unclear. We evaluated the usefulness of routine intradermal cefazolin skin testing and its relationship with the history of β-lactam hypersensitivity. Methods The electronic medical records of patients who underwent intradermal cefazolin (0.3 mg/mL) skin testing without negative controls from January 2010 to January 2011 at Seoul National University Bundang Hospital were evaluated. The history of β-lactam hypersensitivity of the patients was taken. Immediate adverse reactions after cefazolin injection were evaluated by searching the electronic medical records for key words and reviewing consultation documents of allergy specialists or dermatologists. The medical records of the patients were reviewed by an allergist. Results There were 13,153 cases of cefazolin skin testing over the 13-month study period. Among the 12,969 cases with negative skin test results, 8 had immediate hypersensitivity related to cefazolin (0.06%). The negative predictive value of cefazolin skin testing alone was 99.94%. The overall positivity rate of cefazolin skin tests was 1.4% (184/13,153). Of the cases with a history of allergy to β-lactams, 15% (6/40) showed a positive cefazolin skin test result compared to only 1.36% (178/13,113) of cases with no such history (P < 0.001) including some false-positive tests. Conclusion The results suggest that routine screening involving cefazolin skin testing without negative controls is not useful for all patients, but could be helpful for those with a history of β-lactam hypersensitivity, although a large prospective study is needed to confirm this. Graphical Abstract |
Databáze: | OpenAIRE |
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