Screening participation after a false positive result in organized cervical cancer screening: a nationwide register-based cohort study

Autor:	Sisse Helle Njor, Mette Tranberg, Pernille Thordal Larsen, Susanne Fogh Jørgensen
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Adult medicine.medical_specialty Biopsy Science Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Article Cohort Studies Cancer screening Danish Young Adult 03 medical and health sciences 0302 clinical medicine Cytology Humans Mass Screening Medicine False Positive Reactions 030212 general & internal medicine Early Detection of Cancer Vaginal Smears Gynaecological cancer Multidisciplinary Last Screening medicine.diagnostic_test business.industry Obstetrics Odds ratio Middle Aged Uterine Cervical Dysplasia medicine.disease Confidence interval language.human_language Colposcopy 030220 oncology & carcinogenesis language Female business Cohort study
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) Larsen, P T, Jørgensen, S F, Tranberg, M & Njor, S H 2020, ' Screening participation after a false positive result in organized cervical cancer screening : a nationwide register-based cohort study ', Scientific Reports, vol. 10, no. 1, 15427 . https://doi.org/10.1038/s41598-020-72279-x Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-72279-x
Popis:	Our aim was to investigate whether receiving a false positive (FP) cervical cytology result affected subsequent cervical cancer screening participation. This Danish nationwide register-based cohort study included 502,380 women aged 22.5–45 attending cervical cancer screening in 2012–2014 with a normal (n = 501,003) or FP (n = 1,377) cytology screening result. A FP result was defined as a cervical cytology showing high grade cytological abnormalities followed by a normal or ‘Cervical Intraepithelial Neoplasia grade 1’ biopsy result. Women were categorized as subsequent participants if they had a cervical cytology within 24–42 months after their last screening or surveillance test. We compared subsequent participation among women with a normal versus a FP result, using odds ratios including 95% confidence intervals. Participation was slightly higher among women with FP results than among women with normal results (71.5% vs. 69.2%, p = 0.058). After adjustment for age and screening history, women with FP results participated significantly more than women with normal results (OR: 1.19, 95% CI 1.06–1.35). Women receiving a FP result did not participate less in subsequent cervical cancer screening than women receiving a normal result. In fact, the use of opportunistic screening seemed to be increased among women receiving a FP result.
Databáze:	OpenAIRE
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