Germanium poisoning: clinical symptoms and renal damage caused by long-term intake of germanium
| Autor: | Kazuo Kobayashi, Katsuya Obara, Takao Watanabe, Hiroshi Sato, Miho Kakizawa, Kaoru Yoshinaga, Michio Hongo, Takao Saito, Tetsuro Tsukamoto, Kei Yamakage |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Pathology Gastrointestinal Diseases Renal function Nonprescription Drugs Anorexia Degeneration (medical) urologic and male genital diseases Gastroenterology Weight loss Internal medicine Intellectual Disability Medicine Humans Myopathy Child Fatigue Aged Proteinuria urogenital system business.industry Germanium Peripheral Nervous System Diseases Anemia General Medicine Middle Aged medicine.disease Peripheral neuropathy Nails Vomiting Female Kidney Diseases medicine.symptom business Hair |
| Zdroj: | Japanese journal of medicine. 30(1) |
| ISSN: | 0021-5120 |
| Popis: | We report five patients who have taken inorganic germanium preparations over a prolonged period. In all cases, the renal function deteriorated with no proteinuria or hematuria. Histological examination of the kidneys showed widespread tubular degeneration and interstitial fibrosis with minor glomerular abnormalities. Most patients had gastrointestinal symptoms such as vomiting, anorexia and weight loss; one patient had peripheral neuropathy and myopathy. A considerable amount of germanium was detected in the hair or nails of these patients. These cases clearly show that abuse of inorganic germanium compounds can induce renal damage with various extrarenal manifestations. |
| Databáze: | OpenAIRE |
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